The grant application of Mijke Lambregtse-van den Berg has been approved within the ZonMw program Goed Gebruik Geneesmiddelen.Posted by Admin on October 2013
Congratulations to Mijke and the group of collaborators involved in this study!
Stop or Go? Tapering antidepressants in pregnancy: a pragmatic multicenter RCT to investigate risk and benefits for mother and child.
About 2% women use Selective Serotonin Reuptake Inhibitors (SSRIs) during pregnancy for symptoms of anxiety and/or depression. SSRI use in pregnancy is controversial. On the one hand SSRIs may be toxic to the intrauterine developing child, on the other hand, relapse of depression and/or anxiety during pregnancy holds risks for mother and child. Among patients and professionals there is an urgent need for evidence from randomized studies to make rational decisions around continuing or tapering of SSRIs during pregnancy. No such studies exist to date.
The aim of this study is to investigate the effect of guided tapering of SSRI and additional preventive cognitive therapy in early pregnancy as compared to continuation of SSRIs during pregnancy. We will include 200 women who use an SSRI at their first antenatal visit (<16 weeks gestation), without clinical anxiety and/or depression. Women will be randomized to either continuation or guided tapering of SSRI under clinical management and additional preventive cognitive therapy.