MRace awarded Veerle Bergink with an Erasmus MC Fellowship 2016! Posted by Admin on September 2016
This grant will allow Veerle to expend her research and research group focused on
Postpartum psychosis (PP) is an acute and life-threatening psychiatric emergency with an incidence of approximately 1 in 1000 primiparous women. The relative risk for affective psychosis during the first month postpartum is 23 times higher than any other period in a woman’s life. Suicide risk is drastically increased in the first year postpartum with a mortality rate ratio of 289 compared to mothers with no psychiatric history.
In this study we will investigate the hypothesis of an immune related
etiology of postpartum psychosis. Specifically, we will examine the association between severe postpartum psychiatric disorders and autoimmune disorders in a large
population-based cohort. In an independent clinically-ascertained cohort, we will perform the first-ever brain imaging study in PP. The hypothesis is that the autoimmune
pathophysiology of PP may result in white matter abnormalities.
In addition, we will utilize both the population-based and clinically-ascertained cohorts to elucidate predictors of the disease course. By combining the prospective OPPER study cohort and population-based Danish birth registry, this proposal is strongly positioned to significantly advance our understanding of the pathophysiological mechanisms underlying postpartum psychosis, and elucidate the long-term clinical disease course.